Facilities for the Program are located on campus in the FitzGerald Building as well as at a satellite office at The Toronto Hospital. Day-to-day functions of the Program are handled by the Program Director, Dr. C. Wittnich, and Administrative Coordinator, Victoria Simpson, with the guidance of the Executive Committee.

Thanks to all the faculty, students, and participants in our activities for another successful year!

Dr. Carin Wittnich

COLLABORATING DEPARTMENTS

Faculty: Medicine

Physical Education and Health

Clinical: Department of Medicine

Department of Surgery

Department of Anaesthesia

Graduate: Department of Clinical Biochemistry

Department of Community Health

Department of Exercise Sciences

Department of Pharmacology

Department of Physiology

Institute of Medical Science

Laboratory Medicine and Pathobiology

Other: The Centre for Cardiovascular Research

Institute of Biomedical Engineering

EXECUTIVE COMMITTEE

Dr. C. Wittnich (Director)
Dr. M. Plyley (Exercise Science)
Dr. M. Rabinovitch (Lab. Med. Pathobiology)
Dr. C. Forster (Pharmacology)
Dr. D.H. Osmond (Physiology)
Dr. R.D. Weisel (IMS)
Dr. C-C. Liew (Clinical Biochemistry)
Dr. M. Ojha (IBME)
Dr. D. Cheng (Anaesthesia)
Dr. Vivek Rao (Student Representative)

COURSES OFFERED

PROGRAM SPONSORED ACTIVITIES

Annual Cardiovascular Scientific Day - May 21, 1998

The Annual Scientific Day, hosted by the Cardiovascular Sciences Collaborative Program, University of Toronto and the Centre for Cardiovascular Research (CCR), is organized to bring together faculty and students interested in cardiovascular sciences. The aim is to provide an update in the frontiers of cardiovascular science and each symposium focuses on either clinical or basic science research. Attendees are encouraged to actively participate, either in the form of poster presentation or oral discussion, promoting cross-fertilization of ideas and assist research direction within our own cardiovascular community.

The scientific day was held at the Inn on the Park where over 350 registrants enjoyed a pleasant day of camaraderie, excellent science, and good food. This year the focus was on "Cardiac Issues: Past, Present and Future". A central featured symposium consisted of a number of speakers both local and invited. Dr. Victor J. Dzau, Chairman, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston was the Annual Isadore E. Smith Lecturer, hosted by the CCR. He discussed "Innovative Molecular Approaches for Revascularization". This extremely well received talk was then followed by a presentation on "Angiogenesis and Vascular Protection: Targets for Gene Transfer" (Dr. Duncan Stewart), and one on "Surgical Angiogenesis by Cell Transplantation" (Dr. Richard Weisel). Then Dr. Craig R. Smith, Chief, Div. of Cardiovascular Surgery and Director, Cardiopulmonary Transplantation, Columbia Presbyterian Medical Center gave his views on "Progress in Transmyocardial Revascularization". The morning was topped off by a featured research session where four of our dynamic researchers gave talks on "Endogenous Inhibitors of Cardiac Hypertrophy" (Dr. T.G. Parker), "Gene Therapy for Myocardial Revascularization" (Dr. T.M. Yau), "New Insights into Vessel Wall Repair After Angioplasty and Stenting" (Dr. B.H. Strauss), and "Oxygen Therapy and the Failing Heart" (Dr. G.E. Newton). After a very pleasant lunch, the afternoon featured The Harald Sonnenberg Symposium which was held to honor Dr. Harald Sonnenberg who retired in 1998 following a long and illustrious career. Dr. Sonnenberg was honored for his unique contributions to integrative physiology focusing on renal sodium handling and hemodynamics. The session covered "Neural and Hormonal Aspects of Cardiorenal Integration" and was highlighted by a presentation from Dr. Sonnenberg who gave an overview on "Na, ECF Volume and ANP in the Heart". His talk was followed with "ANF and the Autonomic Nervous System" (Dr. U. Ackermann), "Interactions Between ANP and the Sympathetic Nervous System in Humans" (Dr. J.S. Floras), "Lessons from "Dead" Physiologists" (Dr. M. Halperin) and finally "Growth Factors and Renal Hemodynamics" (Dr. J.W. Scholey). Simultaneous sessions rounded out the afternoon and focused on the following topics: adult congenital heart disease, frontiers in organ preservation and pathobiology of cardiovascular disease.

There were 40 abstracts submitted for the poster session, which was expanded to an hour, permitting individual short presentations by each of the six poster finalists. An additional hour of poster viewing was available during the breaks and over lunch. These posters highlighted our cardiovascular trainees in their particular area of interest. Poster prizes, in the form of textbooks, were generously provided by Lippincott-Ravin Publishers (1st Prize), and Williams & Wilkins Publishers (2nd and 3rd Prizes).

1st Prize - S.M. Wells ~~ Structural mechanical relations in the developing thoracic aorta (Co-Supervisors: Drs. L. Adamson/L. Langille) 2nd Prize - M.A. Borger ~~ Does rapid rewarming during cardiopulmonary bypass increase neuropsychological impairment? (Supervisor: Dr. R.D. Weisel) 3rd Prize - W.J. Wallen ~~Gender differences in the hearts adaptation to afterload (Supervisor: Dr. C. Wittnich)

Continuing medical education credits were issued for this meeting; continuing the high quality of scientific content (6.5 hours of category 1 credit toward the AMA Physicians Recognition Award and 9.35 MOCOMP credits for the Royal College of Physicians and Surgeons of Canada). Faculty could use these credits for their professional development.

My thanks are extended, once again, to industry for their continued financial support and generosity which is so essential to the success of this meeting. Major sponsorship included Bristol-Myers Squibb, Hoechst Marion Roussel Canada, Merck Frosst Canada, Medtronic of Canada, Parke-Davis, Pfizer Canada, St. Jude Medical Canada, and Schering Canada. Because of their support, we were able, once again, to provide an open registration and complimentary luncheon.

Students who completed the Cardiovascular Sciences Collaborative Program were recognized at the Awards ceremony and included Bryce Cowan, PhD (Supervisor: Dr. M. Rabinovitch), Vivek Rao, PhD (Supervisor: Dr. R.D. Weisel), Jack Wallen, MSc (Supervisor: Dr. C. Wittnich), Bin Zhou, PhD (Supervisor: Dr. M. Rabinovitch), and Meredith Ford, MSc (Supervisor: Dr. G. Wilson).

The Annual Cardiovascular Scientific Day continues to be the highlight of our academic year!

Medtronic Travel Award

Two competitions were held (spring and fall) for the Medtronic Travel Award. This award, established in 1995, helps to defray costs of travel for Program students presenting their research work at recognized scientific meetings. Students supported by this award this academic year were:

Fall 1997:

Warren Ball: In Vitro Evaluation of TFG-b1 and IGF-I Expression in Idiopathic Hypertrophic Cardiomyopathy (HCM). Annual Meeting of the Canadian Cardiovascular Society, October 1997 (Supervisor: Dr. Ren-Ke Li, IMS).

Catherine Mason: Bioengineering patent ductus arteriosus in post-natal lambs. American Heart Association, November 1997 (Supervisor: Dr. M. Rabinovitch, LMP).

Spring 1998:

Andrea Burry: Apoliprotein D is Regulated by RNA Binding Protein Light Chain 3 of Microtubule Associated Protein 1. 1998 Experimental Biology Meeting, April 1998 (Supervisor: Dr. M. Rabinovitch, LMP).

Bigelow Book Prize

The Bigelow Book Prize consists of 2 books written by Dr. W.G. Bigelow entitled "Cold Hearts" and "Mysterious Heparin". This prize was established in 1995 by the Cardiovascular Sciences Collaborative Program to recognize and honour a pioneer clinician and scientist in the field of cardiovascular sciences. Awardees should exemplify the personal traits of Dr. Bigelow -- curiosity, drive, and scientific integrity. The award is given in every year that a qualified student is identified. Qualifications include sustained academic scientific excellence, innovative experimental approaches, original discoveries and good scientific productivity. Some weight is given to work that has recognizable clinical relevance, especially that which promises to improve patient care.

1995 - Dr. John S. Ikonomidis
1996 - Ms. Shona M. Torrance
1997 - Dr. Vivek Rao
1998 - Dr. Bryce Cowan

This year, an Annual Bigelow Luncheon, held at Hart House, was instituted to bring together the previous and current awardees and their supervisors. This provided a delightful opportunity to chat informally with Dr. Bigelow.

Inside the Heart Lecture Series

For this academic year the lecture series was focused in two main areas: Hormones and Molecular. A number of interesting speakers, once again, contributed their time and knowledge. Topics covered were vast and the emphasis continues to be to cover a broad spectrum from molecular and genetic through to whole organ and systems in specific and focused subject areas.

Part of this lecture series includes the Pfizer Canada Featured Symposia:

Dr. Jean Davignon, OC, MD, CSPQ, FRCPC, FRSC
Director, Hyperlipidemia and Atherosclerosis Research Group
Professor, Faculty of Medicine, University of Montreal
"The Pleiotropic Effects of Lipid Lowering Drugs"

1st Annual "Cardiovascular Disease Update"

The first annual Cardiovascular Disease Update, sponsored by Bristol-Myers Squibb and hosted by the Cardiovascular Sciences Collaborative Program, was successfully held on May 2, 1998 at the Weston Prince Hotel, Toronto. The half day event was attended by 96 family physicians, internists and trainees from across metro Toronto and focused on vascular issues and ischemic heart disease. CME credits were issued by the University of Toronto for 4 Mainpro-MI credits and 4.8 MOCOMP credits. The purpose of this half day event is to provide clinical insight into the diagnosis and treatment of current cardiovascular disease from a bench-to-bedside perspective.

Each session was accompanied by audience discussion which continued informally during the buffet luncheon. The speakers and topics were:

Dr. J.C. Monge, Cardiologist, St. Michael's Hospital
"Plasma Endothelin: Predictor of Cardiac Death"

Dr. Frank Silver, Neurologist, The Toronto Hospital
Director, Toronto Hospital Acute Stroke Investigation Unit
"Stroke Prevention: An Update"

Dr. Beth Abramson, Cardiologist, The Toronto Hospital
Founder, Women's Heart Clinic, The Toronto Hospital
"Management of Women with Ischaemic Heart Disease"

Dr. Shaun Goodman, Cardiologist, St. Michael's Hospital
Director, Cardiac Prevention and Rehabilitation Centre
"Cardiovascular Events Reduction: Beyond Surrogate Endpoints"

Dr. Michael Bentley-Taylor, Chief, Division of Cardiology, Toronto East General Hospital
"Therapeutic Implications of New Antiplatelet Therapy"

Summer Activities

The Collaborative Program, along with the Division of Cardiac Surgery, Department of Surgery, ran another very successful summer program. Applicants included undergraduate and medical school students from the University of Toronto as well as other Universities. The Collaborative Program provided a number of summer scholarships to help students who were unable to procure funding. Over the course of the summer, weekly seminars were presented by graduate students currently enrolled in the Collaborative Program and covered a range of topics with both clinical and basic science relevance. As well, the summer students are given the opportunity to present their summer work. An "end-of-summer" barbeque is held for both faculty and students in August.

This highly successful program is enjoyed by all that participate.

ADVERTISING MATERIAL

World Wide Web

The Cardiovascular Sciences Collaborative Program continues to maintain its own web site under the Faculty of Medicine. The layout of the web site was created to be quick to load and graphically pleasing. Quick access buttons include the program, faculty, departments, applications, etc. and provide detailed information. This web site is updated regularly and is continually undergoing expansion. Please check out our site at http://www.library.utoronto.ca/cardiosci/ to learn more about cardiovascular sciences.

Collaborating departments are encouraged to provide hypertext links to the Collaborative Program on their web site.

Other material that continues to give the Program exposure includes the brochure, the Scientific Day pamphlets and posters, various industry sponsored seminars, and the Inside the Heart Lecture Series notices posted on campus. Collaborating departments also display the Program brochure.

PROGRAM FACULTY

Faculty are divided into 3 categories (Full, Associate, and Affiliate) depending on their SGS status.

FULL: U. Ackermann, L. Adamson, C.E. Bayliss, D. Bradley, F. Coceani, J. Coles, J. Edelson, C.R. Ethier, J.S. Floras, S. Fremes, A.I. Gotlieb, K.W. Johnston, P.G. Kalman, B.L. Langille, H. Lenskyj, C-C. Liew, P. Liu, P. McLaughlin, D.A.G. Mickle, L. Mickleborough, R.I. Ogilvie, M. Ojha, D.H. Osmond, T. Parker, M.J. Plyley, M. Rabinovitch, M. Sefton, N.A. Shaikh, I. Sherman, A.S. Slutsky, M.J. Sole, G. Steiner, D.E. Stewart, D.J. Stewart, S.G. Thomas, P. Walker, R.D. Weisel, G. Wilson, C. Wittnich, T-W. Wu, E.L. Yeo

ASSOCIATE: P. Backx, M Bendeck, E. Conway, J.M. Goodman, L.S. Goodman, J. Irvine, G.F. Lewis, M. Locke

AFFILIATE: A.G. Adelman, R.J. Burns, J. Butany, D. Cheng, D. Courtman, C.M. Feindel, J. Fisher, R-K. Li, T. Lindsay, R. McLean, P. Murphy, J. Parker, L. Schwartz

Two of our faculty (Drs. R. Hegele and C. Forster) have left the University of Toronto and we wish them well in their new positions.

Retired Members: R.S.C. Cobbold, M.D. Silver, and H. Sonnenberg

PROGRAM STUDENTS

Student Newsha Azizi Warren Ball Karim Bandali Michael Borger Andrea Burry Andrew Campbell Gideon Cohen Negin Liaghati-Nasseri Catherine Mason Vaska Micevski Stephen Milone Hani Najm Stacy O'Blenes Rohan Shahani Shona Torrance Dimitra Trambakoulos Jack Wallen

Supervisor U. Ackermann R-K Li C. Wittnich R. Weisel M. Rabinovitch D. Stewart R.D. Weisel S. Fremes M. Rabinovitch D. Stewart J. Parker C. Wittnich M. Rabinovitch T. Lindsay D. Osmond C. Wittnich C. Wittnich

Degree MSc MSc PhD PhD MSc MSc PhD MSc PhD PhD MSc MSc MSc MSc MSc PhD PhD

Department Physiology IMS Physiology IMS Pathology IMS IMS IMS Pathology IMS Pharmacology IMS Pathology IMS Physiology IMS Physiology

CONVOCATED STUDENTS/FOLLOW-UP

Bryce Cowan, MD/PhD, Laboratory Medicine and Pathobiology (Supervisor: Dr. M. Rabinovitch) has returned to medical school at the University of Toronto.

Vivek Rao, PhD, Institute of Medical Science (Supervisor, Dr. R.D. Wiesel) has returned to Cardiac Surgical Residency training, University of Toronto.

Jack Wallen, MSc, Physiology (Supervisor: Dr. C. Wittnich) has continued with his doctoral graduate training under the supervision of Dr. Wittnich at the University of Toronto.

Bin Zhou, PhD, Laboratory Medicine and Pathobiology (Supervisor: Dr. M. Rabinovitch) has continued his training as a Post-doctoral Fellow in the United States.

Meredith Ford, MSc, Physiology (Supervisor: Dr. G. Wilson) has continued on with her doctoral training.

Due to personal reasons, Cathy Carlyle (PhD) and Kyle Harrow (PhD) have dropped out of their graduate training.

STUDENT ACHIEVEMENTS

K. Bandali - John Hepburn Award, UofT
- Teaching Recognition, UofT
- Doctoral Fellowship, UofT
- PMAC/MRC Summer Scholarship

M. Borger - Research Fellow, Heart & Stroke Foundation of Canada
- Second Prize, Terrence Donnelly Resident Research Day, St. Michael's Hospital
- Student Presentation-2nd Prize, Cardiovascular Sciences Scientific Day, CCR/UofT
- Reviewer, Annals of Thoracic Surgery
- Guest Reviewer, Circulation Surgical Supplement A. Burry
- Edward Christie Stevens Fellowship, Faculty of Medicine, UofT
- American Society for Investigative Pathology Student Travel Award, Experimental Biology '98 Meeting G. Cohen
- Guest Reviewer, Annals of Thoracic Surgery
- Miriam Neveren Memorial Award, Postgraduate Medicine, UofT
- Starr Medals Award, Postgraduate Medicine, UofT
- Joseph M. West Research Award, Postgraduate Medicine, UofT
- PSI Resident Research Award, Postgraduate Medicine, UofT
- Finalist/Runner-Up, Vivien Thomas Young Investigator Award, American Heart Assoc., Council on Cardiothoracic and Vascular Surg.
- Finalist, Gallie Bateman Research Competition, Dept. Surgery, UofT

B. Cowan
- Research Traineeship, Heart and Stroke Foundation of Canada
- 1998 Bigelow Book Prize, Cardiovascular Collaborative Program, UofT

C. Mason
- Edward Christie Stevens Fellowship, Faculty of Medicine, UofT
- Medtronic Travel Award, Cardiovascular Collaborative Program, UofT
- Predoctoral Travel Awardee, American Society for Cell Biology Mtg.
- Travel Awardee, American Society for Investigative Pathology
- George Brown Memorial Award, Medical Student Research Day, UofT
- Medical Research Council MD/PhD Studentship

S. Milone - Travel Award, Merck and Co. Ltd. - Certificate of Attendance, American College of Cardiology 47th Ann Mtg
- Young Investigator Travel Award, International Society of Hypertension
- Certificate of Attendance, Int'l Society of Hypertension 17th Ann Mtg

H. Najm - Chief, Saudi Postgraduate Trainees, UofT
- Fellowship, Saudi Mission, Saudi Arabia

S. O'Blenes - Research Fellowship, Heart and Stroke Foundation of Ontario
- Evelyn McGloin Fellowship, Heart and Stroke Foundation of Ontario
- Trainee Award, Canadian Society for Clinical Investigation

R. Shahani - Life Sciences Summer Scholarship, Cardiovascular Collaborative Program, UofT
- Runner-Up, Undergraduate Research Poster Competition, 17th Annual Frontiers in Physiology Symposium, Dept. of Physiology, UofT
- UofT Open Scholarship, Institute of Medical Sciences

S. Torrance - Research Fellowship, Ontario Ministry of Health D. Trambakoulos - UofT Open Scholarship

J. Wallen - Postgraduate Scholarship, NSERC - Special Top-Up Award, Dept. of Physiology, UofT
- John Hepburn Award, Dept. of Physiology, UofT

DIRECTOR'S COMMENTS:

In its' sixth year, the Cardiovascular Sciences Collaborative Program (CSCP) continues to serve its constituents and develop appropriate liaisons with departments with an interest in cardiovascular sciences. Enrolment has increased as shown in the following graph where it can be seen that during the current academic year we had 12 Masters and 12 PhD trainees active in the program. Aside from 2 students who chose not to continue their graduate training for personal reasons, the number of students who convocated increased to 5. Enrolment also increased 71% to 24 students. Bound copies of each graduating students' thesis is kept in the Program office.

Annual student meetings ensure continued satisfaction with the program. Our postgraduate follow-up shows that the graduates of this past year have gone on to pursue either academic or research careers (refer to Convocated Students/Follow-Up section).

During the course of this past year there have been numerous administrative and departmental changes in the Faculty of Medicine. To accommodate these changes the Program has reaffirmed its connections with the Department of Community Health and initiated a tie with the new Faculty of Physical Education and Health, accommodating the Exercise Science group who transferred from Community Health and are now their own graduate department within the new faculty.

This past year the CSCP awards programs helped support a number of our trainees. The Medtronic of Canada Travel Award monies helped a number of students to attend scientific meetings and present their work. As well, the $63,000 we raised and were able to endow allowed the successful launch of the OSOTF bursary which will provide much needed financial relief to deserving students in the Program. These funds will be available on an annual basis to help those Program students with demonstrated academic and research excellence in financial need.

The Bigelow Book Prize, in recognition of an outstanding graduate student in the Program, continues to be the highlight of the year. Apart from the annual luncheon, a plaque will be issued to commemorate this annual event.

The 1st Annual Cardiovascular Update was conceived and jointly run with the generous support of Bristol-Myers Squibb. This half day event provides a clinical update and insights to interested trainees, specialists and general practitioners in the cardiovascular field. Each year a different focus will be highlighted.

Funds in support of the Program's infrastructure continues to be a source of concern. Initiatives continue and corporate sponsors such as Bristol-Myers Squibb and Merck Frosst Canada are recognized for their outstanding annual support of graduate education in cardiovascular sciences at the University of Toronto. A more permanent solution is required if we hope to allow student enrolment to increase beyond the current manageable level.

The new MSC3060/3061 modular course design has met with resounding success. Having 4 modules to select from has made the course mandated at the PhD level an easy option to fulfill and reviews have reflected this. Frequent review of the course content occurs to ensure that current technologies and research foci that are leading edge are represented. This is critical if they are to serve as our flagship courses for our trainees.

For the 1998-99 academic year, we plan to continue our current activities to the best of our abilities and pursue the following priorities:

1. Create a 5 year plan for the Program
2. Actively recruit students to the Program once infrastructure assured
3. Further develop CME programs
4. Examine the cardiovascular graduate courses offered and revamp where needed
5. Target research residents for recruitment into formal graduate program where appropriate
6. Permanent salary support for one full-time Administrative Assistant

PUBLICATIONS - STUDENTS

Borger MA, Rao V, Weisel RD, Ivanov J, Cohen G, et al: Deep sternal wound infection: Risk factors and outcomes. Ann Thorac Surg 1998;65:1050-1056.

Cohen G, Christakis GT, Buth KJ, Joyner CD, Morgan CD, Sever J, Rao V, Borger MA, Goldman BS: Early experience with stentless versus stented valves. Circulation 1997;96:II76-II82.

Cohen G, Ivanov J, Weisel RD, Rao V: Aprotinin and dipyridamole for the safe reduction of postoperative blood loss. Ann Thorac Surg 1998:65:674-683.

Cowan B, Zhou B, Gauldie J, Rabinovitch M: Different mechanisms underlie elafin and alpha1-proteinase inhibitor repression of IL-1b stimulated fibronectin synthesis in cultured porcine coronary artery smooth muscle cells. Circulation Research, 1998.

Milone SD, Parker JD: Nitrate tolerance and angiotensin. UofT Medical Journal, 1997;70(3):176-180.

Najm H, Coles JG, Endo M, et al: Complete atrioventricular septal defect: Results of repair, risk factors and freedom from reoperation. Circulation 1997;96(SuppleII):311-315.

Najm H: Intracardiac fluid resuscitation in penetrating cardiac wounds. A case report. Injury 1997;28:231-232.

Percy ME, Wong S, Bauer S, Liaghati-Nasseri N, et al: Iron metabolism and human ferritin heavy chain cDNA from adult brain with an elongated untranslated region: New findings and insights. The Analyst 1998;123:41-50.

Rao V, Cohen G, Weisel RD, Shiono N, Nonami Y, Carson SM, Ivanov J, Borger MA, Cusimano RJ, Mickle DAG: Optimal flow rates for integrated cardioplegia. J Thorac Cardiovasc Surg 1998;115:226-235.

Rao V, Weisel RD, Buth KJ, Cohen G, Borger MA, et al: Coronary artery bypass grafting in patients with non-dialysis-dependent renal insufficiency. Circulation 1997;96:II38-II45.

Whiteside C, Dessureault S…Torrance SM, et al: Women in biomedical research - addressing the challenges. Clin Invest Med 1997;20:268-272.

Wittnich C, Wallen WJ: Gender differences in response to dietary manipulation in rats with hypertension and myocardial hypertrophy. Am J Clin Nutr 1997;66:1428-1435.

PUBLICATIONS - FACULTY

Aaron SD, Valenza F, Volgyesi G, Mullen JBM, Slutsky AS, Stewart TE: Inhibition of exhaled nitric oxide production during sepsis does not prevent lung inflammation. Crit Care Med 1998;26(2):309-314.

Adamson SL, Myatt L, Byrne BMP: Regulation in umbilical blood flow. IN: Fetal and Neonatal Physiology, Second Edition. (Eds, Polin RA, Fox WW) W.B. Saunders, Philadelphia, PA 1998:977-989.

Alderman E, Bourassa M, Califf R… Schwartz L, et al: The influence of diabetes on 5 year mortality and morbidity in a randomized trial comparing CABG and PTCA in patients with multivessel disease. Circulation 1997;96:1761-1769.

Ando S, Dajani HR, Floras JS: Frequency domain characteristics of muscle sympathetic nerve activity in heart failure and healthy humans. Am J Physiol 1997;273(Regulatory, Integrative and Comparative Physiology 42):R205-R212.

Asokumar B, Cheng DCH, Chung F, Karski J, et al: Pharmacokinetics of doxacurium chloride during normothermic and hypothermic cardiopulmonary bypass surgery. Can J Anaesth 1998;45:515-520.

Babaei S… Bendeck MP, Stewart DJ: Role of nitric oxide in the angiogenic response in vitro to basic fibroblast growth factor. Circ Res 1998;82:1007-1015.

Babensee JE, Sodhi RNS, Sefton MJ: X-ray photoelectron spectroscopy (XPS) surface analysis of HEMA-MMA microcapsules. J Biomat Sci Polym Ed 1997;8:655-665.

Baker B, Dorian P, Sandor P, Shapiro C, Schell C, Mitchell J, Irvine MJ: Electrocardiographic effects of fluoxetin and doxepin in patients with major depressive disorder. J Clin Psychopharmacol 1997;17:15-21.

Bartfay WJ… Sole MJ, Lehotay D, Liu P: The synergistic effects of vitamin E and selenium in iron-overloaded mouse hearts. Can J Cardiol 1998;14(7):937-941.

Basmadjian D, Sefton MV: Coagulation on biomaterials in flowing blood: Some theoretical considerations. Biomaterials 1997;18:1511-1522.

Batchelor WB, Butany J, Liu P, Silver MD: Cardiac metastases from primary cervical squamous cell carcinoma: Three case reports and review of the literature. Can J Cardiol 1997;13(8):767-772.

Boehler A, Chamberlain D, Kesten S, Slutsky AS et al: Lymphocytic airway infiltration as a precursor to birous obliteranation in a rat model of bronchiolitis obliterans. Transplantation 1997;64(2):311-317.

Boehler A, Chamberlain D, Xing Z, Slutsky AS, et al: Adenoviral-mediated IL-10 gene transfer inhibits post-transplant fibrous airway obliteration in an animal model of brochiolitis obliterans. Human Gene Therapy 1998;9(4):541-551.

Bonafede N, Schwartz L: Acute coronary artery occlusion likely due to thrombus occurring during coronary angiography: Report of a case. Cathet Cardiovasc Diagn 1998;43:460-462.

Borger MA, Rao V, Weisel RD, et al: Deep sternal wound infection: Risk factors and management. Ann Thorac Surg 1998;65:1050-1056.

Brenner IKM, Thomas SG, Shephard RJ: Spectral analysis of heart rate variability during heat exposure and repeated exercise. Eur J Applied Physiol, Eur J Applied Occupational Physiol 1997;76(2):145-156.

Brugada R, Sole MJ, Wigle ED, Liew C, Roberts R, Marian AJ: Role of candidate modifier genes on the phenotypic expression of hypertrophy in patients with hypertrophic cardiomyopathy. J Investig Med 1997;45:542-551.

Burns RJ: Effects of RheothRx on mortality, morbidity, left ventricular function, and infarct size in patients with acute myocardial infarction. Collaborative Organization for RheothRx Evaluation (CORE) incl. Circulation 1997;96:192-201.

Butany J, David T, Ojha M: Histological and morphometric analyses of early and late aortocoronary vein grafts and distal anastomoses. Can J Cardiol 1998;6(14):671-677.

Byrne BM, Howard RB, Morrow RJ, Whiteley KJ, Adamson SL: Role of the L-arginine/nitric oxide pathway in hypoxic fetoplacental vasoconstriction. Placenta 1997;18:627-634.

Caldarone CA, Najm KH, Coles JG, et al: Surgical management of pulmonary vein stenosis after repair of total anomalous pulmonary venous drainage. IN: Proceedings of the 2nd World Congress of Pediatric Cardiology and Cardiac Surgery 1998:703-705.

Caldarone CA, Van Arsdell GS, Coles JG, Black MD, et al: Age-stratified analysis of valves and valved conduits in the pulmonary circulation for congenital heart disease: A 30-year experience. J Thorac Cardiovasc Surg 1998.

Cantor WJ, Daley P, Iwanochko M, Clarke J, Cusimano RJ, Butany J: Cardiac transplantation for Fabry's Disease. Can J Cardiol 1998;14(1):81-84.

Cheng DCH: Fast track cardiac surgery: Economic implications in postoperative care. J Cardiothorac Vasc Anesth 1998;12:72-79.

Cheng DCH: Heart Transplantation. IN: Anaesthesia (Eds Klinck JR, Lindop MJ) Chapter 6, Anaesthesia and Intensive Care for Organ Transplantation. London, Chapman & Hall Ltd. 1998:77-88.

Cheng DCH: The drug addicted patient. Can J Anaesth 1997;44:R101-106.

Chlorakis A, Langille BL, Adamson SL: Cardiovascular responses attenuate with repeated nitric oxide synthesis inhibition in conscious fetal sheep. Am J Physiol 1998;274:H1472-H1480.

Cho A, Mitchell L, Koopmans D, Langille BL: Effects of changes in blood flow rate on cell death and cell proliferation in carotid arteries of immature rabbits. Circ Res 1997;81:328-337.

Chu EK, Ribeiro SP, Slutsky AS: Heat stress increases survival rates in lipopolysaccharide-stimulated rats. Crit Care Med 1997;25(10):1727-1732.

Cohen EA, Sykora K, Kimball B, et al, Schwartz L, Adelman AG: Clinical outcomes of patients more than one year following randomization in the Canadian Coronary Atherectomy Trial (CCAT). Can J Cardiol 1997;13(9):825-830.

Cohen G, Ivanov J, Weisel RD, Rao V, Mohabeer M, Mickle DAG: Aprotinin and dipryridamole for the safe reduction of postoperative blood loss. Ann Thorac Surg 1998;65:674-683.

Cohen G, Weisel RD, Rao V, Mickle DAG: Does lethal reperfusion injury exist in cardiac surgery? J Thrombosis and Thrombolysis 1997;4:87-88.

Colangelo S, Langille BL, Steiner G, Gotlieb AI: Alterations in endothelial F-actin microfilaments in rabbit aorta in hypercholesterolemia. Arterioscler Thromb Vasc Biol 1998;18:52-56.

Cowan DB, Lye SJ, Langille BL: Regulation of connexin 43 gene expression by mechanical loads. Circ Res 1998;81:786-793.

De la Pompa JL…Langille BL, Crabtree GR, Mak TW: Role of the NF-Atc transcription factor in morphogenesis of cardiac valves and septum. Nature 1998;392:182-186.

DeCampos KN, Keshavjee S, Liu M, Slutsky AS: Optimal inflation volume for hypothermic preservation of rat lungs. J Heart Lung Transplant 1998;17(6):599-607.

Devitt JH, Kurret MM, Cohen MM, Fish K, Fish P, Murphy PM, Szalai JP: Testing the raters: Inter-rater reliability during observation of simulator performance. Can J Anaesth 1997;44:925-928.

Devlin G, Lazzam L, Schwartz L: Mortality related to diagnostic cardiac catheterization. The importance of left min coronary disease and catheter induced trauma. Intl J Card Imaging 1997;13:379-384.

Devlin G, Schwartz L, Drouin K, Lima WC, Marquis JF: The short- and long-term outcome of left internal mammary artery angioplasty. J Interven Cardiol 1997;10:301-305.

Di Stefano I, Koopmans DR, Langille BL: Modulation of carotid arterial growth by increased blood flow in the rabbit carotid artery. J Vasc Res 1998;35-1-7

Duncan AC, Sefton MV, Brash JL: Effect of C4- C8- and C18- alkylation of poly(vinyl alcohol) hydrogels on the absorption albumin and fibrinogen from buffer and plasma: Limited correlation with platelet interactions. Biomaterials 1997;18:1585-1592.

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Floras JS, Tsuyuki RT, Yusuf S, Rouleau JL, et al for the RESOLVD Pilot Study Investigators: Combination neurohumoral blockade with ACE inhibitors, angiotensin II antagonists and beta-blockers in patients with congestive heart failure: Design of the randomized evaluation of strategies for left ventricular dysfunction (RESOLVD) pilot study. Can J Cardiol 1997;13:1166-1174. (Member of the Steering Committee)

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Johnston KW, Lindsay TF: Mesenteric ischemia: Current surgical techniques. IN: Vascular Surgery: Twenty Years of Progress. (Eds Yao JTS, Pearce WH) Appleton & Lange Publishers, Stanford, Connecticut 1997:219-226.

Jones PL, Crack J, Rabinovitch M: Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the avb3 integrin to promote epidermal growth factor receptor phosphorylation and growth. J Cell Biol 1997;139:279-293.

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Kesten S, Dzyngel B, Chapman KR, Zamel N, Tarlo S, Malo JL, Slutsky AS: Defining the asthma phenotype for the purpose of genetic analysis. J Asthma 1997;34(6):483-491.

Khaykin Y, Dorian P, Baker B, Shapiro C, Sandor P, Mironov D, Irvine J, Newman D: Autonomic correlates of antidepressant treatment using heart-rate variability analysis. Can J Psychiatry 1998;43:183-186.

Kirwan L, Goodman JM: The benefits of an exercise program for the elderly. Long Term Care 1998;1:32-33.

Koetter KP, Hilker T, Genzwuerker H, Lenz M, Maleck, Petroianu GA, Fisher JA: A randomized comparison of rescurer positions for intubation on the ground. Prehospital Emergency Care. 1997;1:96-99.

Lamarche B, Uffelman KD, Steiner G, Barrett PHR, Lewis GF: Analysis of particle size and lipid composition as determinants of the metabolic clearance of human high density lipoproteins in a rabbit model. J Lipid Res 1998;39:1162-1172.

Lester W, Gotlieb AI: The endocrinology of the cardiovacular system. IN: functional Endocrine Pathology. (Eds. Kovacs K, Asa S) Blackwell 1998.

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Lewis GF, Uffelman KD, Lamarche B, Cabana VG, Getz GS: Production of small HDL particles after stimulation of in vivo lipolysis in hypertriglyceridemic individuals. Studies before and after triglyceride-lowering therapy. Metabolism 1998;47(2):234-242.

Lewis GF, Vranic M, Harley P, Cigacca A: Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans. Diabetes 1997;46:1111-1119.

Lewis GF: Free fatty acid regulation of VLDL secretion. Curr Opinion in Lipidol 1997;8(3):146-153.

Lewis GF: Lipid metabolism, bimonthly update. Curr Opinion in Lipidol 1998;9:171-173. (editorial review)

Li R-K, Li GM, Mickle DAG, Weisel RD, Merante F, Luss H, Rao V, Christakis GT, Williams WG: Over-expression of transforming growth factor beta 1 and insulin-like growth factor-I in the patheins with idiopathic hypertrophic cardiomyopathy. Circulation 1997;96:874-881.

Li R-K, Mickle DAG, Weisel RD, Mohabeer MK, Zhang J, Rao V, Jia Z-Q: The natural history of fetal rat cardiomyocytes transplanted into adult rat myocardial scar tissue. Circulation (Suppl) 1997;96:III79-III187.

Li R-K, Sole MJ, Mickle DAG, Schimmer J, Goldstein D: Vitamin E and oxidative stress in the heart of the cardiomyopathic syrian hamster. Free Rad Biol & Med 1998;24(2):252-258.

Li R-K, Yau T, Sakai T, Mickel DAG, Weisel RD: Cell transplantation to repair the broken heart. Can J Cardiol 1998;14:735-744.

Liu M, Slutsky AS: Anti-inflammatory therapies: Application of molecular biology techniques in intensive care medicine. Intensive Care Med 1997;23:718-731.

Liu P: The role of cytokines in myocarditis. IN: The Role of Immune Mechanisms in Cardiovascular Disease. (Eds. Schultheiss HP, Schwimmbeck P) Springer-Verlag, Berlin 1997:44-56.

Liu P: The role of inducible nitric oxide synthase (iNOS) in myocardial disease: A functional duality. IN: Endothelial Modulation of Cardiac Function. (Eds. Shah AJ, Lewis MJ) Harwood Academic Publishers 1997:91-102.

Martino T…Liu P: Cardiovirulent coxsackieviruses and the decay-accelerating factor (CD55) receptor. Virology 1998;244:302-314.

Massie MJ, Muskin P, Stewart DE: Psychotherapy with a woman at high risk for developing breast cancer. Gen Hosp Psychiat 1998;20:189-197.

Mavrogiannis L, Anula KP, Kariyawasam P, Osmond DH: Blood pressure raising effects of activated coagulation factor XII. Can J Physiol Pharmacol 1997;75(12):1398-1403.

Maziak DE, Lindsay TF, Marshall JC, Walker PM: The impact of multiple organ dysfunction on mortality following ruptured abdominal aortic aneurysm repair. Ann Vasc Surg 1998;12(2):93-100.

McLaughlin PR, Gladstone P for the DAIS Project Group: Diabetes atherosclerosis intervention study (DAIS): Quantitative coronary angiographic analysis of coronary artery atherosclerosis. Catheterization and Cardiovasc Diagn 1998;44:249-256.

Mickleborough LL, Tagaki Y, Ohashi M: Left ventricular aneurysm: Linear closure. IN: Mastery of Cardiothoracic Surgery. (Eds Kaiser LR, Kron IL, Spray TL) Lippincott-Raven, Philadelphia 1998:438-445.

Moore JA, Ethier CR: Oxygen mass transfer calculations in large arteries. ASME J Biomechanical Engineering 1997;17:469-475.

Moore JA, Steinman DA, Ethier CR: Computational blood flow modelling: Errors associated with reconstructing finite elements models from magnetic resonance images. J Biomechanics 1998;31:179-184.

Mulholland DL, Gotlieb AI: Valvular interstitial cells - regulator of the cardiac valve structure and function. Cardiovasc Pathol 1997;6:167-174.

Murphy P, Edelist G, Byrick RJ, Kay JC, Mullen JB: Relationship of fat embolism to maemodynamic and echocardiographic changes during cemented arthroplasty. Can J Anaesth 1997;44:1293-1300.

Najm HK, Coles JG, Endo M, et al: Complete atrioventricular septal defects: Results of repair, risk factors, and freedom from reoperation. Circulation 1997;Suppl II:II311-315.

Najm HK, Williams WG, Coles JG, Rebeyka IM, Freedom RM: Pulmonary atresia with intact ventricular septum. Results of the fontan procedure. Ann Thorac Surg 1997;63:669-675.

Najm KH, Caldarone CA, Smallhorn JF, Coles JG: A sutureless technique for the relief of pulmonary vein stenosis utilizing in-situ pericardium. J Thorac Cardiovasc Surg 1998;115:468-470.

Niimura H, et al, Sole MJ, Roberts R, Seidman J, Seidman C: Human cardiac myosin binding protein C mutations cause late-onset familial hypertrophic cardiomyopathy. N Engl J Med 1998;338:1248-1257.

Nulman I, Rovet J, Stewart DE, et al: Neurodevelopment of children exposed in utero to antidepressant drugs. N Eng J Med 1997;4:258-262.

O'Brien W, Karski JM, Cheng DCH, Carroll-Munro J, Peniston C, Sandler AN: Routine chest x-ray on admission to intensive care unit after heart surgery: Is it of any value? J Thorac Cardiovasc Surg 1997;113:130-133.

Osmond DH, Movrogiannis L, Cotter BR: Potent "new pressor protein" related to coagulation FXII is potentiated by inhibition of angiotensin converting enzyme. J Hypertension 1998;16:311-320.

Pandey AS, Rakowski H, Mickleborough LL, Butany JW, Omran A, Parker TG: Right heart pulmonary embolism in transit: A review of therapeutic considerations. Can J Cardiol 1997;13(4):397-402.

Pandey AS, Stewart DJ, Cernacek P, Dawood F, Wen WH, Liu P: Chronic endothelin-1 blockade preserves myocardial contractility in dilated cardiomyopahty. J Cardiovasc Pharmacol 1998;31:S306-S308.

Park J, Lemieux S, Lewis FG, Kuksis A, Steiner G: Chronic exogenous insulin and carbohydrate supplementation increase de novo VLDL triglyceride fatty acid production in the rat. J Lipid Res 1997;38:2529-2536.

Peltekian KM, Wong F, Liu P, Logan AG, Sherman M, Blendis LM: Cardiovascular, renal and neurohumoral responses to single large-volume paracentesis in patients with cirrhosis and diuretic-resistant ascites. Am J Gastroenterol 1997;92:394-399.

Pendino JC, Nannini LJ, Chapman KR, Slutsky AS, Molfino NA: Effect of inhaled furosemide in acute ashma. J Asthma 1998;35(1):89-93.

Penninger JM, Pummerer C, Liu P, et al: Cellular and molecular mechanisms of murine autoimmune myocarditis. APMIS 1997;105:1-13.

Picard P, Smith PJW, Monge JC, Stewart DJ: Expression of endothelial factors after arterial injury in the rat. J Cardiovasc Pharamcol 1998;31(Suppl.1):S323-S327.

Plyley MJ, Olmstead BJ, Noble EG: Time course of changes in the capillarization of hpertrophied rat plantaris muscle. J Appl Physiol 1998;84:902-907.

Rahman MA, Hara K, Floras JS: Influence of prior exercise on stroke volume to pulse pressure ratio in young subjects with hypertension or dilated cardiomyopathy. Can J Physiol Pharamcol 1997;75:1232-1240.

Ranieri VM, Brienza N, Santostasi S, et al, Slutsky AS: Impairment of lung and chest wall mechanics in patients with acute respiratory distress syndrome. Am J Respiratory and Crit Care Med 1997;156:1082-1091.

Rao V, Cohen G, Weisel RD, et al, Mickle DAG: Optimal flow rates for integrated cardioplegia. J Thorac Cardiovasc Surg 1998;115:226-235.

Rao V, Feindel C, Weisel RD, Boylen P, Cohen G: Donor blood perfusion improves myocardial recovery following cardiac transplantation. J Heart Lung Transplantation 1997;16:667-673.

Rao V, Weisel RD, Buth K, et al, Fremes S, Goldman B, Christakis G: Coronary artery bypass grafting in patients with non-dialysis dependent renal insufficiency. Circulation 1997;96:38-45.

Rapanos T, Murphy P, Szalai JP, Kay JC: Indomethacin in conjunction with morphine for balanced analgesia after cardiac surgery. Anesth Anal 1998;86:No4S.

Reidy MA, Bendeck MP: The development of arterial lesions: A process controlled by multiple factors. IN: Coronary Restenosis. From Genetics to Therapeutics. (Ed. Feuerstein GZ) Marcel Dekker Inc. 1997.

Reutens DC…Stewart DJ: L-arginine infusion increases basal but not activated cerebral blood flow in humans. J Cerebral Blood Flow Metabolism 1997;17(3):309-315.

Ritvo PG, Irvine MJ, et al: A critical review of research related to family physician-assisted smoking cessation interventions. Cancer Prevention & Control 1997;1:289-303.

Robinson GE, Stewart DE: New reproductive technologies. IN: Textbook of Women's Health. (Ed. Wallis LA) Lippincott-raven, Philadelphia, PA 1998:687-689.

Robinson GE, Stewart DE: Premenstrual syndrome. IN: Textbook of Women's Health. (Ed. Wallis LA) Lippincott-raven, Philadelphia, PA 1998:699-701.

Rongen GA, Brooks SC, Ando S, Abramson BL, Floras JS: Angiotensin AT1 receptor blockade abolishes the reflex sympatho-excitatory response to adenosine. J Clin Investigation 1998;101:769-776.

Rongen GA, Brooks SC, Ando S, Dajani JR, Abramson BL, Floras JS: Neural and hypotensive effects of angiotensin receptor blockade. Hypertension 1998;31(Part 2):378-383.

Rongen GA, Brooks SC, Ando S, Senn BL, Notarius CFR, Floras JS: Caffeine abstinence augments the systolic blood pressure response to adenosine in humans. Am J Cardiol 1998;81:1382-1385.

Rosen B, Irvine J, Ritvo P, et al, Murphy J, Stewart D: Patients understanding of the risk of infertility treatment: A pilot study. Fertility and Sterility 1997;68:90-94.

Rosen B, Irvine J, Ritvo P, Shapiro H, Stewart DE, et al: The feasibility of assessing women's perceptions of the risks and benefits of fertility drug therapy in relation to ovarian cancer risk. Fertility and Sterility 1997;68:90-94.

Rubin BB, Marshall J, Lindsay TF…Walker PM: Discovery of a novel phospholipase A2 isoform in human neutrophils. Surgical Forum 1997;XLVIII:386-389.

Saccomanno PM, Kavanagh BP, Cheng DCH, Snadler AN: A randomized, double-blind comparison of benzodiazepine alone versus prospective benzodiazepines, morphine and perphenazine for cardiac premedication. Can J Anaesth 1997;44:146-153.

Sandhu R, Diaz RJ, Mao GD, Wilson GJ: Ischemic preconditioning differences in protection and susceptibility to blockade with single versus multi-cycle transient ischemia. Circulation 1997;96(3):984-995.

Sandler AN, Cheng DCH, Kavanagh BP: Lung Transplantation. IN: Anaesthesia (Eds Klinck JR, Lindop MJ) Chapter 10, Anaesthesia and Intensive Care for Organ Transplantation. London, Chapman & Hall Ltd. 1998:121-136.

Schneider Jr, Lindsay TF: The internet and vascular surgery: A brief description of the internet, the world wide web, and some of the vascular surgical resources available. Vasc Surg 1997;5:605-613.

Schwartz CE, Chesney M, Irvine MJ, Keefe FJ: The control group dilemma in clinical research: Applications for psychosocial and behavioral medicine trials. Psychosomatic Med 1997;59:362-371.

Schwartz L, Blew B, Bui S: Intracoronary-stent placement for coronary artery disease. The Lancet 1997;350:113-114.

Seidl M, Stewart DE: A review of alternative treatments for menopausal symptoms. Can Fam Phys 1998;44:1299-1305.

Seidl M. Stewart DE: A qualitative study of menopausal women's experiences with alternative health care. Can Fam Phys 1998;44:1271-1274.

Shirai T, Rao V, Weisel RD, Ikonomidis JS, Li R-K, Tumiati LC, Merante F, Mickle DAG: Preconditioning human cardiomyocytes and endothelial cells. J Thorac Cardiovasc Surg 1998;115:210-219.

Shnek ZM, Foley FW, et al, Irvine J: Helplessman, self-efficacy, cognitive distortions, and depression in multiple sclerosis and spinal cord injury. Ann Behavior Med 1997;19:287-294.

Silkoff PE, Caramori M, Tremblay L, et al, Slutsky AS, Zamel N, Keshavjee S: Exhaled nitric oxide in human lung transplantation. A non-invasive marker of acute rejection. Am J Respiratory and Crit Care Med 1998;157:1822-1828.

Sit AJ, Coloma FM, Ethier CR, Johnson M: Factors affecting the pores of the inner wall of Schlemm's Canal. Invest Ophthalmology Visual Sci 1997;38:1517-1525.

Slutsky AS, Tremblay LN: Pulmonary perspective: Multiple system organ failure: Is mechanical ventilation a contributing factor? Am J Respiratory and Crit Care Med 1998;157:1721-1725.

Slutsky AS: Genetics of asthma: A primer. Can Respiratory J 1998;5:1-5.

Slutsky AS, Zamel N, and the University of Toronto Genetics of Asthma Research Group: Genetics of asthma: The University of Toronto Program. Am J Respiratory and Crit Care Med (Supplement) 1997;156:S130-S132.

Steiner G, Tkác I, Uffelman KD, Lewis GF: Important contribution of lipoprotein particle number to plasma triglyceride concentration in Type 2 diatbetes. Atherosclerosis 1998;137:211-214.

Steiner M, Lamont J, Steinberg S, Stewart DE, et al: Effect of fluoxetine on menstrual cycle length in women with premenstrual dysphoria. Obstets and Gynecol 1997;90:590-595.

Steinman DA, Ethier CR, Rutt BK: A unified analysis of spatial and velocity displacement artifacts in phase contrast measurements of complex flows. J Magnetic Resonance Imaging 1997;7:339-346.

Stewart DE, Abbey SA, Boydell K, Meana M: What makes women tired? J Women's Health 1998;7:69-76.

Stewart DE, Robinson GE: Postpartum disorders. IN: Textbook of Women's Health. (Ed. Wallis LA) Lippincott-raven, Philadelphia, PA 1998:675-677.

Stewart DE, Robinson GE: Introduction. IN: A Clinician's Guide to Menopause. (Eds. Stewart DE, Robinson GE) Am Psychiatric Press Inc. 1997:1-7.

Stewart DE: Women's health comes of age CMAJ 1997;157:1711-1712.

Stewart DE: Plasma endothelin: Predictor of cardiac death? Prespectives in Cardiology Supplement September 1997:15-19.

Stewart TE, Meade MO, Cook DJ, et al, Slutsky AS: Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome. N Eng J Med 1998;338(6):355-361.

Stiskal JA, Dunn Ms, Shenna AT, et al, Rabinovitch M: Alpha 1-proteinase inhibitor therapy for the prevention of chronic lung disease of prematurity: A randomized controlled trial. Pediatrics 1998;101:89-94.

Tai TC Lye SJ, Adamson SL: Expression of prostaglandin E2 receptor subtypes in the developing sheep brainstem. Molecular Brain Res 1998;57:161-166.

Taylor BV, Oudit GY, Irvine J, Kalman PG: Smoking and cardiovascular disease: Clinical manifestations, pathophysiology and methods of smoking cessation. University of Toronto Medical Journal 1997;75:10-15.

Their JGW, Liu Y-A, Coceani F: ATP-gated potassium channel activity of pulmonary resistance vessels in the lamb. Can J Physiol Pharmacol 1997;75:1241-1248.

Theis JGW, Toyoda O, Coceani F: Effect of endothelium removal on prostaglandin and nitric oxide function in pulmonary resistance arteries in the lamb. Can J Physiol Pharmacol 1998;76:182-187.

Thompson K, Kobayashi J, Childs T, Wigle D, Rabinovitch M: Endothelial and serum factors which include apolipoprotein A1 tether elastin to smooth muscle cells inducing serine elastase activity via tyrosine kinase-mediated transcription and translation. J Cell Physiol 1998;174:78-89.

Tishler S, Popma J, Schwartz L: Coronary angioplasty of a posterolateral branch with severe proximal vessel tortuosity. Cathet Cardiovasc Diagn 1997;41:426-429.

Tkác I, Kimball BP, Lewis GF, Ufellman KD, Steiner G: The severity of coronary atherosclerosis in Type 2 diabetes mellitus is related to the number of circulating triglyceride-rich lipoprotein particles. Arterioscl Thromb Vasc Biol 1997;17(12):3633-3638.

Tkacova R, Hall M, Liu P, Bradley TD: Effect of continuous positive airway pressure on mitral regurgitation fraction and atrial natriuretic peptide in patients with heart failure. J Am Coll Cardiol 1997;30:739-745.

Tkacova R, Liu P, Hall M, Bradley TD: Left ventricular volume in patients with heart failure and Cheyne-Stokes respiration during sleep. Am J Resp Crit Care Med 1997;156:1549-1555.

Tsoporis JN, Marks A, Kahn HJ, Butany JW, Liu PP, O'Hanlan D, Parker TG: S100beta inhibits alpha 1-adrenergic induction of the hypertrophic phenotype in cardiac myocytes. J Biol Chem 1997;272:31915-31921.

Urchuk SN, Fremes SE, Plewes DB: In vivo validation of MR pulse pressure measurement in an aortic flow model: Preliminary results. Magnetic Resonance in Med 1997;38:215-223.

Walsh M, Thomas SG, Woodhouse LJ, Finch E: Knee physical impairment and functional limitation: A comparison of individuals one year after total knee arthroplasty to healthy controls. Physical Therapy 1998;78(3):248-258.

Wells SM, Langille BL, Adamson SL: In vivo and in vitro mechanical properties of the sheep thoracic aorta in the perinatal period and adulthood. Am J Physiol 1998;274:H1749-H1760.

Wells W, Plyley M, Duffin J: Changes in the ventilatory sensitivity to carbon dioxide and stroke length of swimmers over a seven week training cycle. World Congress on Sports Science and Medicine of Swimming. Jyvaskyla, Finland. 1998.

White M, Cernacek P, Courtemanche M, Stewart DJ, et al: Impaired endothelin-1 release in tilt-induce syncope. Am J Cardiol 1998;1:460-464.

White M, Courtemanche M, Stewart DJ, et al: Age and gender-related changes in endothelin and catecholamine release and in autonomic balance in response to head-up tilt. Clin Sci 1997;93:309-316.

Whiteside C, Dessureault S, Dickstein J, et al, Stewart DE: Women in biomedical research - addressing the challenges. Clin Invest Med 1997;20:268-272.

Wigle D, Thompson K, Yablonsky S, Jones PL, Zaidi S, Coubler C, Rabinovitch M: AML1-like transcription factor induces serine elastase activity in ovine pulmonary artery smooth muscle cells. Circ Res 1998;83:252-263.

Wong F, Sniderman K, Liu P, Blendis L: The mechanism of the initial natriuresis after transjugular intrahepatic portosystemic shunt. Gastroenterology 1997;112:899-907.

Yemets IM, Williams WG, et al, Coles JG, Rebeyka IM, Freedom RM: Pulmonary valve replacement late after repair of tetralogy of fallot. Ann Thorac Surg 1997;64(2):526-530.

Zeng LH, Rootman DS, Burnstein A, Wu J, Wu TW: Morin hydrate: A better protector than purpurogallin of corneal endothelial damage by zanthine oxidase and SIN-1. Curr Eye Res 1998;17:149-152.

Zeng LH, Wu J, Fung B, Mickle D, Wu TW: Comparative protection against oxyradicals by three flavonoids on cultured endothelial cells. Biochem Cell Biol 1997;75:717-720.

Zhou B, Boudreau N, Coulber C, Hammarback J, Rabinovitch M: Microtubule-associated protein 1 light chain 3 is a fibronectin mRNA-binding protein linked to mRNA translation in lamb vascular smooth muscle cells. J Clin Invest 1997;100:3070-3082.