Session Notes, JCV3063
Advanced Topics in Cardiovascular Sciences - Vascular
Updated Monday February 25, 2013
January 18, 2013, Introduction to Hemostasis and Thrombosis (M. Rand)
- Article 1: Smith, S. A. (2012-12). Inhibition of polyphosphate as a novel strategy for preventing thrombosis and inflammation. Blood, 120(26), 5103-5110.doi:10.1182/blood-2012-07-444935
- Article 2: Gandhi, C. (2012-12). ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice. Blood, 120(26), 5224-5230.doi:10.1182/blood-2012-06-440255
- Article 2: Supplementary figure legends
January 25, 2013, Integrin Signaling and Function During Thrombosis and Hemostasis (H. Ni)
- Article 1: Wedgwood, S. Apocynin improves oxygenation and increases eNOS in persistent pulmonary hypertension of the newborn. American Journal of Physiology, Lung Cellular and Molecular Physiology, 302(6), L616.doi: 10.1152/ajplung.00064.2011
- Article 2: Battinelli, E. M. Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis. Blood, 118(5), 1359-1369.doi: 10.1182/blood-2011-02-334524
February 8, 2013, Mechanisms of Pulmonary Vessel Physiology and Pathophysiology (J. Belik)
- Article 1: Reheman, A. Plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor. American Journal of Physiology, Lung Cellular and Molecular Physiology, 302(8), 1809-1817.doi: 10.1152/ajplung.00064.2011
- Article 2: Yang, J. Sildenafil Potentiates Bone Morphogenetic Protein Signaling in Pulmonary Arterial Smooth Muscle Cells and in Experimental Pulmonary Hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology, 33(1), 34.doi: 10.1161/ATVBAHA.112.300121
February 15, 2013, Role of Smooth Muscle in Vascular Responses (S-S. Bolz)
- Article 1: Ketsawatsomkron, P. PPAR[gamma] Regulates Resistance Vessel Tone Through a Mechanism Involving RGS5-Mediated Control of Protein Kinase C and BKCa Channel Activity. Circulation Research, 111(11), 1446–1458. doi: 10.1161/CIRCRESAHA.112.271577
- Article 2: Walsh, M. The role of actin filament dynamics in the myogenic response of cerebral resistance arteries. Journal of Cerebral Blood Flow & Metabolism, 33(1). doi: 10.1038/jcbfm.2012.144
February 22, 2013, Mechanisms of Heart Valve Pathophysiology (C. Simmons)
- Article 1: Ling Sun. Ex Vivo Evidence for the Contribution of Hemodynamic Shear Stress Abnormalities to the Early Pathogenesis of Calcific Bicuspid Aortic Valve Disease. PloS one, 7(10), 1 –13.
- Article 2: Walsh, M. Biglycan Induces the Expression of Osteogenic Factors in Human Aortic Valve Interstitial Cells via Toll-Like Receptor-2. Arterioscler Thrombosis, and Vascular Biology, 32:2711-2720. doi: 10.1161/ATVBAHA.112.300116
March 15, 2013, The Elastin Matrix of Vascular Tissue, Regulation of Synthesis and Assembly and Role in Vascular Pathology (F. Keeley)
- Article 1: Alternative splicing and tissue-specific elastin misassembly act as biological modifiers of human elastin gene frameshift mutations associated with dominant cutis laxa. The Journal of Biological Chemistry, 286(26):22055-67. doi: 10.1074/jbc.M111.3279406.
- Article 2: Inhibition of microRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels. Arterioscler Thrombosis, and Vascular Biology, 32(3):756-759. doi: 10.1161/ATVBAHA.111.238113.
- Article 3: MicroRNAs differentially expressed in postnatal aortic development downregulate elastin via 3' UTR and coding-sequence binding sites. PloS ONE, 6(1):e16250. doi: 10.1371/journal.pone.0016250.
March 22, 2013, Vascular Response to Angioplasty Injury (B. Strauss)
- Article 1: Intracoronary Optical Coherence Tomography and Histology at 1 Month and 2, 3, and 4 Years After Implantation of Everolimus-Eluting Bioresorbable Vascular Scaffolds in a Porcine Coronary Artery Model: An Attempt to Decipher the Human Optical Coherence Tomography Images in the ABSORB Trial. Circulation, 2010(122): 2288-2300. doi: 10.1161/CIRCULATIONAHA.109.921528.
- Article 2: Polymer-Free Biolimus A9-Coated Stent Demonstrates More Sustained Intimal Inhibition, Improved Healing, and Reduced Inflammation Compared With a Polymer-Coated Sirolimus-Eluting Cypher Stent in a Porcine Model. Circulation, 2010(3): 174-183. doi: 10.1161/CIRCINTERVENTIONS.109.877522.
Guidelines for JCV3063 Final Written Project:
The final project is a 5 page (single-spaced) minireview on the topic area you have chosen. I would suggest organizing your report in a similar manner to that of a Circulation Research Review article. Since this report will be a relatively short document I would strongly suggest you pick a specific subtopic within the main topic area to avoid getting lost in the literature. The topics may be directly related to those covered in the papers presented in class or they may be distinct from the class discussion. You may, if you wish, incorporate relevant class discussion into your review.
The criteria for grading this assignment will be as follows:
- Quality and thoroughness of the literature review- have you identified the key papers that have defined your topic field? (25 %)
- Quality of scientific writing- do you effectively convey your ideas to a broad readership? (25 %)
- Insight – have you drawn accurate conclusions from the existing literature? What are the future directions for the field? Are there still controversies within the field? (25 %)
- Use of original diagrams to convey your ideas – have you created 2-3 original figures that effectively summarize the key points in your review? (10 %)
- Overall Scientific Appeal- can you convince me that this area is (or should be) the hottest new focus of vascular research? (15 %)
The purpose of this type of document is to raise awareness about a specific research area. You should demonstrate an in-depth understanding of the topic area. You should be able to describe the most difficult biologic problems faced by researchers in the field, the latest experiments that have been done to answer some of those questions and what you think will be important biologic questions for the future of the field. Please feel free to disagree (in a politically correct manner) with the interpretation of published works to prove your point.